Top Clinical Insights: Beyond AKs: Field Cancerization of the Skin
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Clinical Practice
- Studies have shown that nicotinamide 500mg twice daily led to a 23% reduction in new non-melanoma skin cancers at 12 months in immunocompetent patients with at least two non-melanoma skin cancers in the past 5 years.
- Fluorouracil topical is the preferred treatment for immunocompromised patients and patients who are treatment-naive.
- If using fluorouracil and calcipotriene in combination, patients will have a more intense inflammatory reaction than fluorouracil alone, therefore the combination treatment requires a shorter course. Combination therapy is not as good for immunocompromised patients, they should use fluorouracil alone.
- Capecitabine is an oral medication that gets broken down in the body to fluorouracil and can be used in patients with significant field cancerization.