A potent oral anti-oxidants from a fern, Polypodium leucotomas, can be taken 240 mg TID for 12 weeks as an adjunct melasma therapy.
Csyteamine is physiologically synthesized by all mammalian cells as a natural anti-oxidant and could be used an an alternative to treat melasma.
Glutathione, a new skin lightening procedure, is short on evidence and should not be advised.